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Best Nootropics Supplements of 2021

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It’s important that nootropics supplements accommodate the specific objectives of each individual. When embarking upon the journey of selecting the best nootropics supplement for you, it’s important to assess your personal requirements. In other words, you must understand what type of brain supplement is required to boost your cognitive performance. It’s not always easy to choose the right nootropic performance aid since there are many options. There’s a lot to consider, but here are some of the ways in which cognitive enhancers can be helpful:

  • Boosts memory capacity
  • Improves concentration and focus
  • Elevates work performance
  • Mitigates age-related cognitive issues
  • Reduces mental anxiety
Highly Recommended
GenBrain Brain Supplement
GenBrain is a nootropics supplement for your brain with a patented formula. The ingredients in GenBrain include Vitamin B6, amino acids, and various other natural nutrients.
  • Increases brain function
  • Enhances cognitive function

If you’re unfamiliar with nootropics, it’s a good idea to get acquainted with what it is and how it works so you can help your mental performance. In fact, there’s a lot that you can learn about your brain and how you can improve your cognitive function. Below you’ll find a list of five of the best nootropics supplements that are worthy of consideration, while remaining both affordable and effective.[/vc_column_text]

Let's Take A Look At The Top 3

#1 Rated GenBrain

GenBrain Brain Supplement

#2 Rated AlphaBrain

Alpha Brain

#3 Rated NooCube


Achieving peak cognitive performance can completely change many aspects of your life. For starters, a stronger cognitive function enhances your overall brain function, which enables you to better perform both simple and complex tasks. It also impacts your memory and attention span, which is just the tip of the iceberg for connection-making and focus. How your brain functions isn’t necessarily how someone else’s brain functions, which means everyone has different needs. Luckily, this article will share some of the best nootropic supplement options that work to target mental fatigue and all of its symptoms.

About Nootropics

Nootropic supplements are synthetic and natural in origin. It’s an active substance that helps to make the brain function better. There are many other names used for nootropics, such as brain boosters, memory enhancing supplements, cognition enhancers and smart drugs. When nootropics are taken as a prescription, it’s considered a stimulatory drug, which distinguishes it from other forms. The reason why nootropics are prescribed is because they are beneficial in relieving a variety of diseases, such as narcolepsy, Alzheimer’s disease, and Attention Deficit Hyperactivity Disorder (ADHD).

Some of the best nootropic options are completely natural and are intended to improve varied brain functions, while enhancing cognition instead of treating disease. Although they may not necessarily be prescribed for the purpose of treating disease, that doesn’t mean that they don’t have a positive impact that counters a medical condition. These types of nootropics can positively impact concentration, memory, learning, thinking, and various other mental processes that allow for them to be called “smart drugs”. Many consumers are drawn to products with natural ingredients because they are less likely to cause side effects.

Are Nootropics Effective?

Some customers experience promising results when taking non-synthetic nootropics, produced by manufacturers that are established in the industry. However, if your focus is on ensuring the product purchased is effective, it’s important to purchase supplements from a reliable source. As with any other supplements, not all products are of high quality. However, the brands listed above are considered some of the best nootropic options on the market and are likely more effective than other options.

It may come as no surprise that the best nootropic supplements often come with all-natural ingredients. Some studies have shown that natural brain boosters or “smart drugs” are more likely to optimize primary cognitive capacities and contribute to improved overall health and mental wellness by providing the best combination of what the brain needs per day.

There is always a need for additional research when it comes to supplements, especially for brain health. That’s because the brain is one of the most complex organs in the body and it’s important to constantly examine the impact of products consumed, whether natural or synthetic. Continued studies will help people better understand the impact of nootropics. This is important since they are constantly growing in popularity.

The Top Rated For 2020:

1) GenBrain - #1 Best Nootropic for 2020

GenBrain Brain Supplement

GenBrain is a nootropics supplement for your brain with a patented formula. The ingredients in GenBrain include Vitamin B6, amino acids, and various other natural nutrients. This product works by maintaining normal levels of acetylcholine and producing electrical impulses in the brain.

Benefits of GenBrain Nootropic Supplements:

  • Increases brain function- Elevates your mental capacity, which can increase alertness and productivity.
  • Improves memory- Has the potential to improve both short-term and long-term memory so that you can recall specific details about events that occurred or the location of items.
  • Enhances cognitive function- Can potentially strengthen neurotransmitters stored in the brain.
  • Elevates focus- May enhance your ability to concentrate for longer periods of time.

2) Alpha Brain - #2 Best Nootropic for 2020

Alpha Brain

The goal of Alpha Brain is to increase your memory, including your ability to concentrate and recall information. It’s a product with all natural ingredients that can restore your brain to a more youthful state. While people at different ages and stages in life can take Alpha Brain, it’s great for someone dealing with memory issues associated with aging.

Benefits of Alpha Brain Nootropic Supplements:

  • Improves long-term memory- It’s common for people to experience a reduction in memory when there is a cognitive decline. Alpha Brain is a supplement that helps to restore your brain so that your long-term memory is enhanced.
  • Enhances short-term memory- The ingredients in Alpha Brain are specifically designed to improve your short-term memory. The manufacturer of this product focused on creating a formulation that is beneficial in restoring this aspect of your brain.
  • Supports mental acuity- Not having mental sharpness can be challenging. Alpha Brain can restore this aspect of your brain to address a lack of clarity that might exist.
  • Strengthens overall brain function- There are many times when an impaired brain function must be address by protecting the neural pathways. That’s one of the benefits of Alpha Brain; it helps to improve the natural processes that are involved in protecting the brain.

3) NooCube - #3 Best Nootropic for 2020


NooCube is near the top of the list when it comes to nootropics supplements for recharging cognitive performance. It’s formulated with active ingredients that are known to enhance many areas of the brain. Of the many supplements on the market, this is definitely one that’s worth considering because of its formulation and overall effectiveness. One of the reasons why this is a highly regarded product is because it works on different spheres of the brain to target mental fatigue and mental performance.

NooCube is a supplement that stimulates the formulation of new brain cells by targeting each existing brain cell. It also helps the brain with dendrite arborization, which is a biological process that involves the development of new synapses. What’s incredible about NooCube is that the benefits of supplementation last long after taking the product. This is one of the reasons why it’s often ranked among other top products for cognitive performance. In fact, there are many reasons to consider using NooCube.

Benefits of NooCube Nootropics:

  • Improves your ability to learn- Accessing and recalling information becomes easier.
  • Sharpens your ability to concentrate and focus- You are able to pay closer attention to small details and stay focused for long periods of time.
  • Reduces the impact of stress- Soothes the stress that comes with mental fatigue while reducing the impact of anxiety. Also inhibits damage from oxidative stress.
  • Enhances your memory- Enhances your overall mental performance in terms of memory

4) Brain Pill - #4 Best Nootropic for 2020


The cholinergic system in the brain is responsible for sensory perception and it consists of nerve cells that are activated to release acetylcholine during a nerve impulse. Brain Pill helps to stimulate this process within each individual brain cell. It can play an important role in how the nervous system functions. It can also help with learning, concentration and memory, among other functions associated with the brain. Brain Pill has ingredients that have been clinically tested quite rigorously.

Benefits of the Brain Pill Nootropic:

  • Boosts memory- Increases overall memory performance, such as aiding quick recall.
  • Improves concentration- Allows you to focus without distractions.
  • Enhances brain function- Improves overall cognitive function.
  • Fosters improved communication- Allows for clearer processing and responses.
  • Facilitates enhanced learning capabilities- Provides much needed nutrients to each brain cell for better overall performance.
  • Reduces pain- Enhances blood flow around the brain, relieving you of triggers that can cause headaches.

5) Ion Z - #5 Best Nootropic for 2020

Ion Z

As with similar supplements, Ion Z is designed to enhance cognitive functions and overall brain performance. It’s also one of the best nootropics supplements for providing a boost in energy and improving focus. There are quite a few reasons to use Ion Z.

Benefits of Ion Z:

  • Enhances memory- It can be difficult to maintain information during the learning process when there is a decline in cognition. Ion Z is effective at helping with short-term and long-term memory to address this issue.
  • Increases energy- Many people use coffee and energy drinks as a way to eliminate brain fog, however, Ion Z provides a way to feel energized without consuming a ton of caffeine per day.
  • Improves focus- The company that manufactures Ion Z promotes the product for being able to provide “laser-like focus” when you struggle with getting distracted. This product can help you concentrate when you might otherwise lose focus.

What You Should Know About Nootropic Stacks

Nootropic stacking is adding at least two nootropic supplements together to enhance the cognitive benefits. In some instances, people that take nootropics aim to resolve a particular issue involving their brain. When possible, it’s best to simultaneously address multiple issues. It’s also a good idea to boost the overall functioning of your brain and blood flow.

A nootropic stack was made for the purpose of accommodating consumers that want to combat multiple issues. These usually consist of a combination of the Best Nootropics Supplements found on the market. The nootropic stack is often comprised of powerful and wide-ranging active components aimed at aiding multiple cognitive abilities. Creating stacks requires you to choose ingredients that will work together to achieve the desired outcome. In many cases, these ingredients in the nootropic stack work much better together than they could individually as nootropic supplements are made to work together.

Nootropic stacks are effective at enhancing cognition with carefully chosen active substances. The benefits to consumers is a supplement that is of excellent quality.

Here are some of the specific benefits associated with the use of Nootropic stacks:

  • Specific formulation designed to address cognitive issues, such as focus, brain power, concentration, memory and mood.
  • Includes scientifically proven ingredients that are often highly effective.
  • Ingredients tend to be high in quality and possess a purity levels.
  • Often has a significant amount of vitamins, minerals, and antioxidants.
  • Usually has either minimal or not adverse effects.
  • Typically does not include fillers.
  • Usually only needs to be taken once per day.

Is It Safe to Take Nootropic Supplements?

When you’re considering supplementation to support your brain and mental health, it’s important to check with your doctor about which nootropic “smart drug” is best for you. This is because both natural and synthetic supplements have the potential to negatively interact with prescription medication. Your doctor should be aware of the nootropics that you plan to take per day, including the ingredients in the product. This is one of the most important aspects of ensuring safety when supplementing with any product, even when it’s not for the purpose of brain health. This is a general rule of thumb to keep in mind when consuming health products.

As previously mentioned, it’s important to make sure you purchase natural nootropics from a reputable and reliable source. Failure to do so can result in the purchase of a product that contains ingredients not listed on the label, which has the potential to endanger your health. By checking the reviews of a product or asking for recommendations, you can mitigate this issue and find the best retailer for your nootropic needs.

The nootropic products listed above are often recommended because they are often highly rated by consumers. Your goal should be choosing nootropic supplements that you know are of high quality so that you don't have to deal with adverse effects.

Ingredients in Natural Nootropics

There are a long list of natural nootropics on the market that are effective in supporting brain performance and cognitive function. It’s simply a matter of identifying the product that works best for you.

Below are ingredients often found in the Best Nootropics Supplements:

L-theanine: An amino acid that naturally occurs in black tea and green tea. It's one of the best benefits of green tea. It’s beneficial to the brain because it has the ability to increase alpha waves, enhance mental alertness and improve overall cognitive abilities. When combined with caffeine, L-theanine, increases in effectiveness. In fact, it’s most effective when consumed with caffeine.

Caffeine: Coffee and tea are the most common ways in which caffeine is consumed. Caffeine is a natural stimulant that’s highly potent. When consumed in moderation, it has the ability to combat cognitive decline, improve concentration and enhance focus. Another exceptional benefit of caffeine is that it boosts energy levels and promotes vitality. These are benefits that many people around the globe depend upon on a daily basis. The Food and Drug Administration recommends that people avoid consuming more than 400 mg of caffeine daily.

Ginkgo Biloba: This is a plant that has bio-available substances that help to boost cognitive abilities. This is the reason why Ginkgo Biloba is added to many health supplements. As an herbal ingredient, Ginkgo Biloba is potent and can help to eliminate symptoms associated with dementia.

Creatine: This is an amino acid that has become a commonly used ingredient that’s added to many brain health supplements. It’s quite effective and addressing issues associated with cognitive impairment. It’s also know to improve a person’s ability to reason and enhance their short-term memory.

Omega-3 Fatty Acids: This is an ingredient that’s incredibly beneficial when it comes to brain health. In fact, it’s often used to combat issues associated with age-related problems with memory. Omega-3 fatty acids are one of the best supplements for supporting brain health, especially when you prefer natural solutions. Omega-3 fatty acids are highly effective at developing membranes surrounding neurons. It also helps to restore brain cells relatively quickly, which is partly why it’s so great at addressing age-related issues. Omega-3 fatty acids help to keep the nervous system healthy, which is why it’s such a key part of daily nutrition. Since it can be difficult to consume a sufficient amount of nutrient-dense foods that contain omega-3 fatty acids on a regular basis, it’s common for people to take supplements.

How Nootropics Support Brain Health

Nootropics have gained popularity in recent years as many people have incorporate them into their health routine. It’s beneficial for people across generations because there are many reasons why a person might need to improve their memory or enhance their brain function to present themselves as their best.

The term “nootropics” was established by Dr. Corneliu E. Giurgea decades ago. It’s a Greek word that defined as molding the mind into shape. Dr. Giurgea create guidelines for classifying nootropic substances. Here are the characteristics that were required for a substance to be formally called a nootropic:

-Combats issues like low blood pressure that can impede learning and memory processes.

-Protects the brain against different chemical and physical injuries.

-Improves the ability to learn an enhances cognition.

-Cannot cause side effects similar to tradition drugs that are psychotropic in nature.

-Should result in a positive impact on brainstem mechanisms.

-Cannot have high toxicity levels.

Where You Can Buy Nootropics

There are many places to purchase nootropics. You can buy them online, such as on the Amazon website. These are brain boosters or so called smart drugs that are over-the-counter formulations and do not require a prescription. You can also purchase them at pharmacies and other retailers that sell supplements. There are some instances when you can purchase them directly from the manufacturer. Taking nootropics that require a prescription means you must first schedule an appointment with your doctor and he or she will help you choose between the best nootropics for you.

Can Nootropics Help You?

Whether or not a nootropic supplement can help with any issues that you are having will depend on whether you choose the right supplement. You must first get a good understanding of the issue you’re facing. You must also make sure you know which ingredients are included in the product so that you can avoid consuming anything that isn’t beneficial. It’s imperative that you read the labels and check the reviews to see if the claims by the manufacturer align with consumer feedback.

It’s always important to first consult with your doctor regarding any nootropic supplements that are taken because they know your medical history and can make a recommendation based on your specific situation. They can also assess whether a nootropic supplement will negatively interact with other medications you’re taking. You should focus on choosing products with ingredients that are designed to boost cognitive functions.

There are many nootropics that protect the brain, increase your attention span, and improve mental health. If you’re not sure if a nootropic product will work for you, consider starting with a small quantity and increasing it as you confirm that it works well to treat your specific issue.

Overview of Common Ingredients

Acetyl-L-Carnitine: This is an acetylated L-Carnitine that’s a neural antioxidant that is naturally-occurring in the body. Acetyl-L-Carnitine positive affects the function of your brain and is effective at supporting neural pathways. It’s also a compound that’s effective at eliminating side effects that are neurological in nature, such as memory loss, slow cognitive functions. It can also help to mitigate mood swings and help your brain better respond to stressful situations. The potential benefits of Acetyl-L-Carnitine are far-reaching.

Bacopa Monnieri: Bacopa Monnieri has been used medically for centuries. Bacopa Monnieri is a substance that’s extracted from plant leaves that are commonly found in India. However, it also grows in many tropical climates where wetlands exist. Bacopa Monnieri has been an Ayurvedic Medicine solution used for centuries to help people feel calmer and more relaxed. It’s also used to enhance cognitive functions, increase memory and support general brain health.

Bacopa Monnieri is also said to raise serotonin levels so you can feel your best. Additionally, Bacopa Monnieri is known for its association with providing relief to Alzheimer patients as Bacopa Monnieri has a strong correlation with improved memory. However, be sure to drink a lot of water if your nootropic supplement has this ingredient in it, as Bacopa Monnieri is said to cause dry mouth.

DMAE Bitartrate: This is a Dimethylaminoethanol that helps to reduce the amount of buildup of what’s known as the ‘age pigment’ that’s believed to impair the brain’s ability to function properly. DMAE Bitartrate can serve many purposes and it’s known to help mitigate issues like dementia and Alzheimer’s disease. In fact, DMAE Bitartrate can be used to treat many other brain problems related to aging.

Ginko: This is a potent antioxidant that works by stimulating blood flow to the brain, which helps to increase the flow of oxygen. It’s also believed to support cognitive functions and enhance memory, which is great for issues associated with getting older. Ginko is best known for its restorative properties.

Ginkgo Biloba: Healthcare professionals that believe in alternative medic have used Ginkgo Biloba for many years. They believe it can help with many issues associated with the brain and overall health and wellness. For instance, it’s believed to strengthen focus and memory. This is accomplished by promoting the development of neural stem cells. Ginkgo Biloba helps to mitigate the growth of dementia and senility because it increases the amount of oxygen in the brain.

L-Glutamine Hydrochloride: This is an amino acid that’s naturally occurring in the body. It’s a brain sedative that calms erratic behaviors and thoughts. It can also help to deal with anxiety that prevents you from getting a sufficient amount of sleep. If you experience issues associated with your mood, it's best to find a nootropic with L-Glutamine Hydrochloride.

Phosphatidylserine Complex: Known as a super brain food, Phosphatidylserine Complex can improve your overall brain function. It’s an important part of neuronal growth and survival. It can help to stabilize your mood, which is best when dealing with depression. It has also been known to help with controlling ADD and ADHD.

Rhodiola Rosea: This natural ingredient not only has cancer fighting properties, but rhodiola rosea also packs a multitude of other benefits into its tiny flowering buds. Rhodiola rosea works to decrease stress, fight fatigue, and aids overall brain function. Rhodiola rosea, used ceremoniously in Scandinavian countries for centuries, is also known as an ingredient that fights the symptoms of depression, such as lack of physical energy. Rhodiola rosea may even help to control diabetes. Overall, rhodiola rosea is a very strong ingredient with many benefits packed in.

St. John’s Wort: This is a very popular supplement that’s extracted from a plant called Hypericum Perforatum. It’s been used for many years to boost brain health. It’s quite effective at elevating activities of neurotransmitters related to your mood, including dopamine, GABA, serotonin and norepinephrine. If you are considering St. John’s Wort as a supplement, be sure to check with your doctor first because it can have a negative interaction with various medications.

Vinpocetine: This is a supplement that’s native to Europe and found in the periwinkle plant. It’s been used for traditional medicine for many years and can help people suffering from many brain issues, such as dementia. It helps to boost oxygen to the brain and it delivers nutrients to the cerebral tissue.

Potential Side Effects of Nootropics

Brain Pill Side Effects

One of the top priorities when taking nootropics is checking the list of ingredients. You should have a good understanding of how they will impact your body, even when the ingredient is completely natural. There are some ingredients that may have a side effect that doesn't sit well with you, so be sure to check with your doctor about which nootropic is best for you. It’s one reason why it’s necessary to consult with your doctor regarding any nootropics that you plan to take. They can provide the guidance you need to avoid any negative side effects, especially if you are current taking prescription medication. Notably, women that are pregnant should avoid taking even natural nootropics without consulting their doctor.


It’s common to become forgetful, especially as you get older in life. Many people forget where they left their keys or where they parked the car, which can get quite frustrating as time goes on. If you find yourself experiencing these types of situations, a nootropic supplement might be the best solution because a nootropic supplement can restore your brain in many ways. The best nootropic supplements previously listed have been studied for years in clinical trials and have proven effective at enhancing brain health.

If you are ready to try a nootropic supplement for improved brain health, be sure to check with your doctor regarding the ingredients in the supplement that you choose. As previously mentioned, these “smart drugs” can help to ensure that you are able to be and feel your best. The information provided will enable you to assess the benefits of each nootropic option to decide which one will work best for you. Simply put, there are solutions to many brain-related issues, and now is a good time to find what works best for you.

Healthy Body Healthy Mind disclaimer


Alessandra is the mother of two daughters, ages 13 and 23. Natural medicine and a holistic living have been an focus of her life for many years. She has been studying with The Institute for Integrative Nutrition to become a Certified Holistic Health Coach, and is a big part of the wellness community. She is an big fan of yoga, practices meditation, and is presently a nutrition and healthy lifestyle mentor for adults.

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